OC-0077: Towards individualized dose constraints: The QUANTEC radiation pneumonitis model with clinical risk factors
نویسندگان
چکیده
منابع مشابه
Radiation pneumonitis and pulmonary function with lung dose–volume constraints in breast cancer irradiation
PURPOSE We studied symptomatic radiation pneumonitis (RP) and changes in pulmonary function tests (PFTs) after loco-regional radiotherapy (LRRT) with V20 lung constraints in breast cancer (BC). PATIENTS AND METHODS Sixty-four women underwent PFTs before and 5 months after 3D planned LRRT for BC. The incidentally irradiated ipsilateral lung V20 was minimised to <30%. Patients were monitored fo...
متن کاملATM polymorphisms are associated with risk of radiation-induced pneumonitis.
PURPOSE Since the ataxia telangiectasia mutated (ATM) protein plays crucial roles in repair of double-stranded DNA breaks, control of cell cycle checkpoints, and radiosensitivity, we hypothesized that variations in this gene might be associated with radiation-induced pneumonitis (RP). METHODS AND MATERIALS A total of 253 lung cancer patients receiving thoracic irradiation between 2004 and 200...
متن کاملRadiation pneumonitis after hypofractionated radiotherapy: evaluation of the LQ(L) model and different dose parameters.
PURPOSE To evaluate the linear quadratic (LQ) model for hypofractionated radiotherapy within the context of predicting radiation pneumonitis (RP) and to investigate the effect if a linear (L) model in the high region (LQL model) is used. METHODS AND MATERIALS The radiation doses used for 128 patients treated with hypofractionated radiotherapy were converted to the equivalent doses given in fr...
متن کاملReduction of radiation pneumonitis by V20-constraints in breast cancer
INTRODUCTION Adjuvant local-regional radiotherapy (LRRT) is routinely recommended for breast cancer patients. It is well known being related to pulmonary side-effects. We studied post-RT radiological changes on X-ray and CT, and correlated the findings with Quality of Life (QoL), common dosimetric factors and co-variates. The results were compared with a previously reported cohort of 137 irradi...
متن کاملExclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis
BACKGROUND The risk factors for radiation pneumonitis (RP) in patients with chronic obstructive pulmonary disease (COPD) are unclear. Mean lung dose (MLD) and percentage of irradiated lung volume are common predictors of RP, but the most accurate dosimetric parameter has not been established. We hypothesized that the total lung volume irradiated without emphysema would influence the onset of RP...
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ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2013
ISSN: 0167-8140
DOI: 10.1016/s0167-8140(15)32383-5